Interstrand cross-links generated by abasic sites in duplex DNA.
نویسندگان
چکیده
Abasic sites (1, Scheme 1), which are generated by hydrolysis of the glycosidic bonds connecting the heterocyclic nucleobases to the deoxyribose backbone, represent the most common type of damage suffered by genomic DNA.1 Spontaneous hydrolysis yields approximately 10,000 abasic sites per cell per day. In addition, exposure of DNA to radiation, mutagens, and anticancer drugs can lead to the generation of abasic sites.2 Unrepaired abasic sites are mutagenic or cytotoxic.1
منابع مشابه
Interstrand cross-links arising from strand breaks at true abasic sites in duplex DNA
Interstrand cross-links are exceptionally bioactive DNA lesions. Endogenous generation of interstrand cross-links in genomic DNA may contribute to aging, neurodegeneration, and cancer. Abasic (Ap) sites are common lesions in genomic DNA that readily undergo spontaneous and amine-catalyzed strand cleavage reactions that generate a 2,3-didehydro-2,3-dideoxyribose sugar remnant (3'ddR5p) at the 3'...
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 129 7 شماره
صفحات -
تاریخ انتشار 2007